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Mild or early cases of Paget's are asymptomatic, and so most people are diagnosed with Paget's disease incidentally during medical evaluation for another problem. Approximately 35% of patients with Paget's have symptoms related to the disease when they are first diagnosed. [7] Overall, the most common symptom is bone pain. [7]
Paget's disease of the breast is difficult to diagnose by physical exam alone due to its resemblance to dermatitis and eczema. One helpful differentiator is that eczema tends to affect the areola first, and then the nipple, whereas Paget's disease of the breast typically begins at the nipple and spreads outwards.
Paget's disease may refer to several conditions described by Sir James Paget, surgeon and pathologist: Paget's disease of bone (most common use of the term "Paget's disease") Paget's disease of the breast; Paget–Schroetter disease; Paget's abscess; Extramammary Paget's disease (EMPD)
Paget's disease of bone; Acromegaly; Periapical granuloma; Arthritis; Calcinosis; Rheumatic fever; It may be one of the complications of Paget's disease of bone in the form of generalized hypercementosis. It may also be a compensatory mechanism in response to attrition to increase occlusal tooth height.
It is seen in multiple conditions and has been classically described for lepromatous leprosy as well as Paget's disease of bone. It is a dermatological symptom, with characteristic facial features that are visible on presentation, and is useful for focusing on differential diagnosis .
Multisystem proteinopathy (MSP) is a dominantly inherited, pleiotropic, degenerative disorder of humans that can affect muscle, bone, and/or the central nervous system.MSP can manifest clinically as classical amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), inclusion body myopathy (IBM), Paget's disease of bone (PDB), or as a combination of these disorders. [1]
The first case of Paget's disease was described by James Paget in 1874. [3] Radcliffe Crocker , in 1889, then described EMPD following an observation of a patient with urinary carcinoma affecting the penis and scrotum, [ 18 ] showing symptoms that were almost identical to MPD as described by Paget. [ 6 ]
Bone disease is common among the elderly individual, but adolescents can be diagnosed with this disorder as well. There are many bone disorders such as osteoporosis , Paget's disease , hypothyroidism . [ 2 ]