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Tissue hypoxia refers to low levels of oxygen in the tissues of the body and the term hypoxia is a general term for low levels of oxygen. [2] Hypoxemia is usually caused by pulmonary disease whereas tissue oxygenation requires additionally adequate circulation of blood and perfusion of tissue to meet metabolic demands.
The aim is to achieve a systolic blood pressure of 90 mmHg in order to maintain tissue perfusion without inducing re-bleeding from recently clotted vessels. Permissive hypotension is a means of restricting fluid administration until hemorrhage is controlled while accepting a short period of suboptimal end-organ perfusion.
Ischemia can be a partial (poor perfusion) or total blockage. Compartment syndrome is a condition in which increased pressure within one of the body's anatomical compartments results in insufficient blood supply to tissue within that space.
Hypothermia due to decreased perfusion and evaporation of sweat; Thirst and dry mouth, due to fluid depletion; Cold and mottled skin (livedo reticularis), especially extremities, due to insufficient perfusion of the skin; The severity of hemorrhagic shock can be graded on a 1–4 scale on the physical signs.
The cause of inadequate tissue perfusion (blood delivery to tissues) in distributive shock is a lack of normal responsiveness of blood vessels to vasoconstrictive agents and direct vasodilation. [4] There are four types of distributive shock.
Hypovolemia can be recognized by a fast heart rate, low blood pressure, [12] and the absence of perfusion as assessed by skin signs (skin turning pale) and/or capillary refill on forehead, lips and nail beds. The patient may feel dizzy, faint, nauseated, or very thirsty. These signs are also characteristic of most types of shock. [13]
Because of poor blood flow to the tissues, patients may have cold extremities. Less blood to the kidneys and brain can cause decreased urine output and altered mental status, respectively. [9] Other signs may be seen depending on the underlying cause. For example, jugular venous distension is a significant finding in evaluating shock.
Ischemia or ischaemia is a restriction in blood supply to any tissue, muscle group, or organ of the body, causing a shortage of oxygen that is needed for cellular metabolism (to keep tissue alive). [ 3 ] [ 4 ] Ischemia is generally caused by problems with blood vessels , with resultant damage to or dysfunction of tissue, i.e., hypoxia and ...