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Blood cell lineage. The megakaryocyte develops through the following lineage: CFU-Meg (hematopoietic stem cell/hemocytoblast) → megakaryoblast → promegakaryocyte → megakaryocyte. Megakaryocytes are derived from hematopoietic stem cell precursor cells in the bone marrow. They are produced primarily by the liver, kidney, spleen, and bone ...
CFU-GEMM cells are the oligopotential progenitor cells [1] [2] for myeloid cells; they are thus also called common myeloid progenitor cells or myeloid stem cells. "GEMM" stands for granulocyte , erythrocyte , monocyte , megakaryocyte .
The Human Cell Atlas project, which started in 2016, had as one of its goals to "catalog all cell types (for example, immune cells or brain cells) and sub-types in the human body". [13] By 2018, the Human Cell Atlas description based the project on the assumption that "our characterization of the hundreds of types and subtypes of cells in the ...
The megakaryocyte develops through the following lineage: CFU-Meg (hematopoietic stem cell/hemocytoblast) → megakaryoblast → promegakaryocyte → megakaryocyte. The megakaryoblast is derived from colony forming units (CFU-Meg) of hematopoietic stem cells found in red bone marrow.
The number of leukocytes in the blood is often an indicator of disease, and thus the white blood cell count is an important subset of the complete blood count. The normal white cell count is usually between 4 × 10 9 /L and 1.1 × 10 10 /L. In the US, this is usually expressed as 4,000 to 11,000 white blood cells per microliter of blood. [7]
Promegakaryocytes and other precursor cells to megakaryocytes arise from pluripotential hematopoietic progenitors, [2] also known as hemocytoblasts. The megakaryoblast is then produced, followed by the promegakaryocyte, the granular megakaryocyte, and then the mature megakaryocyte. [3]
Haematopoiesis in the bone marrow starts off from a haematopoietic stem cell (HSC) and this can differentiate into the myeloid and lymphoid cell lineages. In order to eventually produce a megakaryocyte, the haematopoietic stem cell must generate myeloid cells, so it becomes a common myeloid progenitor, CFU-GEMM. This in turn develops into CFU ...
Megakaryocyte–erythroid progenitor cells must commit to becoming either platelet-producing megakaryocytes via megakaryopoiesis or erythrocyte-producing erythroblasts via erythropoiesis. [2] [3] Most of the blood cells produced in the bone marrow during hematopoiesis come from megakaryocyte–erythroid progenitor cells. [4]
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