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DNA polymerase alpha, like DNA primase, contains iron-sulfur clusters, that are critical in electron transport that uses DNA itself to transfer electrons at very high speeds; this process is involved in detecting DNA damage, and may also be involved in a feedback between the primase complex and the DNA polymerase alpha.
The free NCBI tool Primer-BLAST integrates primer design and BLAST search into one application, [6] as do commercial software products such as ePrime and Beacon Designer. Computer simulations of theoretical PCR results ( Electronic PCR ) may be performed to assist in primer design by giving melting and annealing temperatures, etc. [ 7 ]
There are two main types of primase: DnaG found in most bacteria, and the AEP (Archaeo-Eukaryote Primase) superfamily found in archaean and eukaryotic primases. While bacterial primases (DnaG-type) are composed of a single protein unit (a monomer) and synthesize RNA primers, AEP primases are usually composed of two different primase units (a heterodimer) and synthesize two-part primers with ...
Dungeons & Dragons: Adventures in the Forgotten Realms is an expansion set for Magic: The Gathering (Magic) released in July 2021.The world of the Forgotten Realms was created by game designer Ed Greenwood around 1967 as a paracosm for his childhood stories [1] and premiered as a campaign setting for the Dungeons & Dragons (D&D) fantasy role-playing game in the Forgotten Realms Campaign ...
Unlike the other known DNA polymerases, PrimPol can initiate replication without the need of an RNA primer and can extend from primers produced by PrimPol. [6] [7] PrimPol preferentially initiates replication using deoxynucleotides, rather than ribonucleotides and will only extend from a nascent DNA chain using deoxynucleotides. PrimPol ...
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