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Also important to know: Most acne treatments typically take at least a few weeks to show results, and some may cause an initial “purge” in which the skin gets worse before it gets better ...
Adapalene, sold under the brand name Differin among others, is a third-generation topical retinoid primarily used in the treatment of mild-moderate acne, and is also used off-label to treat keratosis pilaris as well as other skin conditions. [6] Studies have found adapalene is as effective as other retinoids, while causing less irritation. [7]
Tretinoin is the least expensive of the topical retinoids and is the most irritating to the skin, whereas adapalene is the least irritating but costs significantly more. [1] [100] Most formulations of tretinoin are incompatible for use with benzoyl peroxide. [15]
Synthetic retinoids are utilized in cosmetic formulations, clinical dermatology, and the treatment of some forms of cancer. [1] Retinoids have many important functions throughout the body, including in vision, [2] regulation of skin proliferation and differentiation, growth of bone tissue, immune function, [3] and male fertility. [4]
Tretinoin, also known as all-trans retinoic acid (ATRA), is a medication used for the treatment of acne and acute promyelocytic leukemia. [ 8 ] [ 9 ] [ 10 ] For acne, it is applied to the skin as a cream, gel or ointment. [ 10 ]
It contains clindamycin, as the phosphate, a lincosamide antibacterial; adapalene, a synthetic retinoid; and benzoyl peroxide, an oxidizing agent. [2] It is applied to the skin . [ 2 ]
Meta-analysis of clinical trials has shown this combined therapy to be more effective than either of its ingredients by themselves. [6]The use of adapalene/benzoyl peroxide in combination with oral antibiotics (lymecycline) has been studied; [7] the combination was well tolerated and showed an improved success rate compared to those receiving only antibiotics (47.6% vs. 33.7%, P = 0.002).
[9] [11] Tretinoin and adapalene have demonstrated efficacy in reducing inflammation. [11] Adapalene as a newer retinoid is thought to be more effective and better tolerated than others in this class. [11] As a topical product, it has similar side effects to topical BPO of burning, stinging, drying and scaling which can be managed much the same ...