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JAK inhibitors are used in the treatment of some cancers and inflammatory diseases [1] [2] such as rheumatoid arthritis [3] and various skin conditions. [4] A Janus kinase 3 inhibitor is attractive as a possible treatment of various autoimmune diseases since its function is mainly restricted to lymphocytes.
The cancer treatment drug topotecan is a synthetic chemical compound similar in chemical structure to camptothecin which is found in extracts of Camptotheca (happy tree). [7] Catharanthus roseus. Vinca alkaloids were originally manufactured by extracting them from Catharanthus roseus (Madagascar Periwinkle). [1] Podophyllum spp.
RANKL inhibitor. Osteoporosis, including drug- and cancer-related osteoporosis, giant cell tumour of bone and hypercalcaemia of malignancies: Hypercholesterolaemia, cataract, urinary retention, hypocalcaemia, osteonecrosis of the jaw and anaphylaxis. Gemtuzumab ozogamicin: IV: CD33 antibody that induces apoptosis of the tagged cell. Acute ...
If JAK inhibitors can show similarly impressive results, gain approval, and make a splash, then these blockbuster biologics could have some real competition. While the future is promising that "if ...
Medicinal fungi are fungi that contain metabolites or can be induced to produce metabolites through biotechnology to develop prescription drugs.Compounds successfully developed into drugs or under research include antibiotics, anti-cancer drugs, cholesterol and ergosterol synthesis inhibitors, psychotropic drugs, immunosuppressants and fungicides.
Janus kinase 3 inhibitors, also called JAK3 inhibitors, are a new class of immunomodulatory agents that inhibit Janus kinase 3. They are used for the treatment of autoimmune diseases . The Janus kinases are a family of four nonreceptor tyrosine-protein kinases, JAK1 , JAK2 , JAK3 , and TYK2 .
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