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Microfluidics devices also can simulate the tumor microenvironment, to help to test anticancer drugs. Microfluidic devices with 2D or 3D cell cultures can be used to analyze spheroids for different cancer systems (such as lung cancer and ovarian cancer), and are essential for multiple anti-cancer drugs and toxicity tests. This strategy can be ...
Other applications include capillary gel electrophoresis, water-in-oil emulsions, and biosensors for POC systems. [3] [60] [61] Suspended microfluidic devices, open microfluidic devices where the floor of the device is removed, have been used to study cellular diffusion and migration of cancer cells. [5]
Microfluidic devices make possible the study of a single cell to a few hundred cells in a 3D environment. Comparatively, macroscopic 2D cultures have 10 4 to 10 7 cells on a flat surface. [10] Microfluidics also allow for chemical gradients, the continuous flow of fresh media, high through put testing, and direct output to analytical ...
A microvalve is a microscale valve, i.e. a microfluidic two-port component that regulates the flow between two fluidic ports. Microvalves are basic components in microfluidic devices, such as labs-on-a-chip, where they are used to control the fluidic transport.
The main advantage of paper-based microfluidic devices over traditional microfluidics devices is their potential for use in the field rather than in a laboratory. [61] [62] Filter paper is advantageous in a field setting because it is capable of removing contaminants from the sample and preventing them from moving down the microchannel.
Liquid-liquid extractions can be carried out on digital microfluidic device by taking advantage of immiscible liquids. 9 Two droplets, one containing the analyte in aqueous phase, and the other an immiscible ionic liquid are present on the electrode array. The two droplets are mixed and the ionic liquid extracts the analyte, and the droplets ...
Nanoparticles, microparticles and colloidal clusters in microfluidic devices are useful for functions such as drug delivery. [173] The first particles incorporated in droplet-based systems were silica gels in the micrometer size range in order to test their applications in the manufacturing of displays and optical coatings. [174]
However, there are some drawbacks to using silicon-based devices in biomedical applications such as their high cost and bioincompatibility. [10] Due to being single-use only, larger than their MEMS counterparts, and the requirement of clean room facilities, high material and processing costs make silicon-based bio-MEMS less economically ...