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Long-term use is sometimes described as use not shorter than three months. [2] Benzodiazepines are generally effective when used therapeutically in the short term, [3] but even then the risk of dependency can be significantly high. There are significant physical, mental and social risks associated with the long-term use of benzodiazepines. [3]
After the last dose has been taken, the acute phase of the withdrawal generally lasts for about two months although withdrawal symptoms, even from low-dose use, can persist for six to twelve months gradually improving over that period, [123] [68] however, clinically significant withdrawal symptoms may persist for years, although gradually ...
Long-term use of benzodiazepines can worsen pre-existing depression and anxiety and may potentially also cause dementia with impairments in recent and remote memory functions. [23] Use is widespread among amphetamine users, with those that use amphetamines and benzodiazepines having greater levels of mental health problems and social ...
Clonazepam, sold under the brand name Klonopin among others, is a benzodiazepine medication used to prevent and treat anxiety disorders, seizures, bipolar mania, agitation associated with psychosis, obsessive–compulsive disorder (OCD), and akathisia. [11]
[2] [8] While no dose of clonazolam is considered "safe" due to its lack of research and extreme potency, doses higher than 0.5 mg can cause benzodiazepine overdose in some individuals. [ 2 ] [ 8 ] The effects of a benzodiazepine overdose include sedation, confusion, amnesia, insufficient breathing, loss of consciousness, and death.
Failure to treat benzodiazepine dependence in the elderly can cause serious medical complications. [14] The elderly have less cognitive reserve and are more sensitive to the short (e.g., in between dose withdrawal) and protracted withdrawal effects of benzodiazepines, as well as the side-effects both from short-term and long-term use.
Although benzodiazepines are much safer in overdose than their predecessors, the barbiturates, they can still cause problems in overdose. [19] Taken alone, they rarely cause severe complications in overdose; [161] statistics in England showed that benzodiazepines were responsible for 3.8% of all deaths by poisoning from a single drug. [21]
[1] [2] These medications are usually used for mental illness but may also be given for gastrointestinal or neurological problems. [1] The condition typically develops only after months to years of use. [1] [3] The diagnosis is based on the symptoms after ruling out other potential causes. [1]