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Therefore, most transfusion-dependent thalassemia patients can be diagnosed within the first few years of life, which severe anemia, differed growth, jaundice and hepatosplenomegaly can be observed. Parameters for confirmation includes baseline hemoglobin level <7g/dL, enlargement of liver and spleen (>5 cm) and height in the first 10th percentile.
Hematopoietic stem cell transplantation is also used, especially for patients under 30 years of age with a related, matched marrow donor. [ 5 ] [ 6 ] Aplastic anemia is known to have caused the deaths of Marie Curie , [ 7 ] Eleanor Roosevelt , [ 8 ] Luana Reyes , and Molly Holzschlag .
A retrospective study of 47,970 type 2 diabetes patients, aged 50 years and older, found that patients with an HbA 1c more than 48 mmol/mol (6.5 DCCT %) had an increased mortality rate, [30] but a later international study contradicted these findings. [31] [32] [33]
Type 2 diabetes is typically a chronic disease associated with a ten-year-shorter life expectancy. [ 10 ] [ 26 ] This is partly due to a number of complications with which it is associated, including: two to four times the risk of cardiovascular disease, including ischemic heart disease and stroke; a 20-fold increase in lower limb amputations ...
Recent research has found that people with diabetes are more susceptible to developing multiple co-occurring long-term conditions, which, in turn, can shorten life expectancy.
Hemolytic anemia or haemolytic anaemia is a form of anemia due to hemolysis, the abnormal breakdown of red blood cells (RBCs), either in the blood vessels (intravascular hemolysis) or elsewhere in the human body (extravascular). [2]
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