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Currently there is no regulation on the use of similar antifungal classes in agriculture and the clinic. [1] [38] [39] The emergence of Candida auris as a potential human pathogen that sometimes exhibits multi-class antifungal drug resistance is concerning and has been associated with several outbreaks globally. The WHO has released a priority ...
Itraconazole is a relatively well-tolerated drug (although not as well tolerated as fluconazole or voriconazole) and the range of adverse effects it produces is similar to the other azole antifungals: [22] elevated alanine aminotransferase levels are found in 4% of people taking itraconazole
Efinaconazole, sold under the brand name Jublia among others, is a triazole antifungal medication. It is approved for use in the United States, Canada, and Japan as a 10% topical solution for the treatment of onychomycosis (fungal infection of the nail). [3] [4] Efinaconazole acts as a 14α-demethylase inhibitor. [5] [2]
Ibrexafungerp was approved for medical use in the United States in June 2021. [1] [4] It is the first non-azole oral antifungal drug to be approved by the U.S. Food and Drug Administration (FDA) for the treatment of vaginal yeast infections. [4] The FDA considers it to be a first-in-class medication. [5]
Amphotericin B is an antifungal medication used for serious fungal infections and leishmaniasis. [3] The fungal infections it is used to treat include mucormycosis, aspergillosis, blastomycosis, candidiasis, coccidioidomycosis, and cryptococcosis. [4]
Antifungal resistance to drugs in the azole class tends to occur gradually over the course of prolonged drug therapy, resulting in clinical failure in immunocompromised patients (e.g., patients with advanced HIV receiving treatment for thrush or esophageal Candida infection).