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Adrenal fatigue or hypoadrenia is a pseudo-scientific term used by alternative medicine providers to suggest that the adrenal glands are exhausted and unable to produce adequate quantities of hormones, primarily cortisol, due to chronic stress or infections. [1]
The medical system isn't motivated to take adrenal fatigue seriously, Wilson says, because “there’s no money in it” without drugs that can be prescribed to treat it.
At the most extreme level, for example, are tumors of the adrenal glands, or pheochromocytomas, which commonly lead to high blood pressure that reaches life-threatening levels.
Primary adrenal insufficiency predisposes to higher risk of death, mostly due to infection, cardiovascular disease, and adrenal crisis. [2] Delayed diagnosis can impair quality of life, and lack of treatment brings high mortality. [2] However, with proper diagnosis, monitoring, and treatment, people with adrenal insufficiency can live normally. [3]
Chronic primary adrenal insufficiency is typically characterized by an extended period of malaise, fatigue, anorexia, weight loss, joint and back pain, and skin darkening. Mineralocorticoid and glucocorticoid hormone deficiency must be physiologically replaced in order to treat primary adrenal insufficiency. [18]
Rapid onset of symptoms indicates acute adrenal failure, which is a clinical emergency. [5] An adrenal crisis can be triggered by stress, such as from an injury, surgery, or infection. [1] Addison's disease arises when the adrenal gland does not produce sufficient amounts of the steroid hormones cortisol and (sometimes) aldosterone. [1]