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Interleukin 7 (IL-7) is a protein [5] that in humans is encoded by the IL7 gene. [6] [7] [8] IL-7 is a hematopoietic growth factor secreted by stromal cells in the bone marrow and thymus. It is also produced by keratinocytes, [9] follicular dendritic cells, [10] hepatocytes, [11] neurons, and epithelial cells, [12] but is not produced by normal ...
IL-13 receptor; IL-15 receptor [2] IL-21 receptor [3] The common beta chain (CD131 or CDw131) is shared between the following type I cytokine receptors: GM-CSF receptor; IL-3 receptor; IL-5 receptor. [4] The gp130 receptor (Glycoprotein 130) (also known as gp130, IL6ST, IL6-beta or CD130) is shared between: IL-6 receptor; IL-11 receptor; IL-12 ...
Interleukin 10 (IL-10) is a protein that inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF, and GM-CSF produced by activated macrophages and by helper T cells. In structure, IL-10 is a protein of about 160 amino acids that contains four conserved cysteines involved in disulphide bonds. [ 33 ]
The nomenclature also proposes that IL-1F5 should be renamed to IL-36Ra, because it works as an antagonist to IL-36α, IL-36β and IL-36γ similar to how IL-1Ra works for IL-1α and IL-1β. Another revision was the renaming of IL-1F7 to IL-37 because this suppressing cytokine has many splicing variants , they should be called IL-37a, IL-37b and ...
Moreover, CD25 is an exclusive subunit that entirely binds IL-2, while CD132 binds the shared γc family cytokines (IL-4, IL-7, IL-9, IL-15 and IL-21), and the CD122 subunit binds also IL-15. [5] [24] [25] Soluble IL2RA has been isolated and determined to result from extracellular proteolysis during activation of T lymphocytes. [18]
3589 16156 Ensembl ENSG00000095752 ENSMUSG00000004371 UniProt P20809 P47873 RefSeq (mRNA) NM_001267718 NM_000641 NM_008350 NM_001290423 RefSeq (protein) NP_000632 NP_001254647 NP_001277352 NP_032376 Location (UCSC) Chr 19: 55.36 – 55.37 Mb Chr 7: 4.78 – 4.79 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Interleukin 11 (IL-11 or adipogenesis inhibitory factor) is a protein that ...
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Cytokine receptor common subunit gamma also known as interleukin-2 receptor subunit gamma or IL-2RG is a protein that in humans is encoded by the IL2RG gene. [8] The human IL2RG gene is located on the long (q) arm of the X chromosome at position 13.1, from base pair 70,110,279 to base pair 70,114,423.