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Photodynamic therapy (PDT) is a form of phototherapy involving light and a photosensitizing chemical substance used in conjunction with molecular oxygen to elicit cell death (phototoxicity). [ 1 ] PDT is used in treating acne , wet age-related macular degeneration , psoriasis , and herpes .
The efficacy of antimicrobial photodynamic therapy, using various distinct photosensitizers, has been studied since the 1990s. [ 9 ] [ 7 ] Most studies have yielded positive outcomes, often achieving disinfection levels, as defined by infection control guidelines, exceeding 5 log 10 (99.999%) of microbial inactivation. [ 14 ]
Dental infections tend to also respond better to photothermal therapy than photodynamic therapy, though both have a strong effect. [ 10 ] [ 11 ] [ 12 ] The efficacy of PDT for antimicrobial usage is limited by the properties of the membrane of the target cell such as the electrical gradient ( membrane potential ) and lipid composition.
Gholam A. Peyman (born 1 January 1937) is an Iranian American ophthalmologist, retina surgeon, and inventor. He is best known for his invention of LASIK eye surgery, [2] a vision correction procedure designed to allow people to see clearly without glasses.
The International Joint Commission on Allied Health Personnel in Ophthalmology (IJCAHPO) is an American nonprofit professional association for Allied Ophthalmic Personnel (AOP). Founded in 1969, the IJCAHPO provides certification and education programs for persons in the ophthalmology field.
Sonodynamic therapy can be combined with other therapeutic techniques to enhance treatment efficacy for various types of cancers and diseases. SDT can be combined with photodynamic therapy, chemotherapy, radiation, MRI, and immunotherapy. PDT has often been used in combination with SDT as sonosensitizers are also photosensitive. [1]