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Polar body twinning is a hypothesized form of twinning in meiosis, where one or more polar bodies do not disintegrate and are fertilized by sperm. [2]Twinning would occur, in principle, if the egg cell and a polar body were both fertilized by separate sperms.
Formation of the corpus luteum: From the remaining structures of the follicle, the corpus luteum is formed. At first, there is a clot, which is then replaced by loose connective tissue; the cells that form solid cords are follicular cells and cells of the outer theca (Tecali lutein cells) and internal ( granulosa cells ).
The four main steps of meiosis II are: prophase II, metaphase II, anaphase II, and telophase II. In prophase II, we see the disappearance of the nucleoli and the nuclear envelope again as well as the shortening and thickening of the chromatids. Centrosomes move to the polar regions and arrange spindle fibers for the second meiotic division.
Oocyte (or ovum/egg) activation is a series of processes that occur in the oocyte during fertilization.. Sperm entry causes calcium release into the oocyte. In mammals, this is caused by the introduction of phospholipase C isoform zeta (PLCζ) from the sperm cytoplasm. [1]
These two steps, while not part of folliculogenesis, are included for completeness. They are discussed in their entirety by their respective articles, and placed into perspective by the menstrual cycle article. It is recommended that these three topics be reviewed.
By this time, the oocyte has completed meiosis I, yielding two cells: the larger secondary oocyte that contains all of the cytoplasmic material and a smaller, inactive first polar body. Meiosis II follows at once but will be arrested in the metaphase and will so remain until fertilization.
An assortment of hypotheses exist concerning the biological function of CGFDs and pre-fertilization cortical granule exocytosis. For instance, the formation of the CGFDs may be the oocyte's mechanism for retaining more cortical granules for future use rather than losing them to the polar bodies as the polar bodies extrude from the cell.
Polar body biopsy is the sampling of a polar body of an oocyte. It was first applied clinically in humans in 1987 after extensive animal studies. [ 1 ] A polar body is a small haploid cell that is formed concomitantly as an egg cell during oogenesis , but which generally does not have the ability to be fertilized .