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In 1954 he discovered, confirming his preconception, that people with sickle-cell trait are resistant to the deadly falciparum malaria. In the 1970s, Allison had worked out the enzyme, inosine monophosphate dehydrogenase, as a key molecule of the immune response in autoimmune diseases and in organ transplantation.
A key difference is a malfunction of the innate immune system in autoinflammatory diseases, whereas in autoimmune diseases there is a malfunction of the adaptive immune system. [ 8 ] Symptoms of autoimmune diseases can significantly vary, primarily based on the specific type of the disease and the body part that it affects.
Most autoimmune diseases are sex-related; as a whole, women are much more likely to develop autoimmune disease than men. Being female is the single greatest risk factor for developing autoimmune disease than any other genetic or environmental risk factor yet discovered.
This article provides a list of autoimmune diseases. These conditions, where the body's immune system mistakenly attacks its own cells, affect a range of organs and systems within the body. Each disorder is listed with the primary organ or body part that it affects and the associated autoantibodies that are typically found in people diagnosed ...
Disease Discoverer 2600 BC: Malaria [1] 1900 BC: Rabies: 1600 BC: Cancer: Hippocrates: ca 300: Dengue: Jin Dynasty (266–420) 9th century: Measles: Muhammad ibn Zakariya al-Razi: 14th century: African trypanosomiasis: First described by Arab traders [2] 1798: Color blindness: John Dalton: 1798: Amyotrophic lateral sclerosis: John Dalton: 1881 ...
A key mystery behind one of the most common autoimmune diseases may finally have an answer. Researchers at Northwestern Medicine and Brigham and Women’s Hospital say they’ve discovered a root ...
Noel R. Rose (December 3, 1927 – July 30, 2020), was an American immunologist, pathologist, and molecular microbiologist. He is widely known for pioneering autoimmunity during the 1950s and made several contributions to the field of autoimmunity, which brought in the modern era of research into autoimmune disease.
This discovery led to the understanding of what is now known as autoimmune diseases. [169] To ensure that the person has lupus and not another autoimmune disease, the American College of Rheumatology (ACR) established a list of clinical and immunologic criteria that, in any combination, point to SLE. The criteria include symptoms that the ...