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Ring sideroblasts are named so because iron-laden mitochondria form a ring around the nucleus. It is a subtype of basophilic granules of the erythrocyte, but which can only be seen in bone marrow.
Pappenheimer bodies are abnormal basophilic granules of iron found inside red blood cells on routine blood stain. [1] They are a type of inclusion body composed of ferritin aggregates, or mitochondria or phagosomes containing aggregated ferritin.
Basophilic stippling, also known as punctate basophilia, is the presence of numerous basophilic granules that are dispersed through the cytoplasm of erythrocytes in a peripheral blood smear. They can be demonstrated to be RNA .
Sideroblastic anemia or sideroachrestic anemia is a disease in which the bone marrow produces ringed sideroblasts rather than healthy red blood cells (erythrocytes). [58] It may be caused either by a genetic disorder or indirectly as part of myelodysplastic syndrome. [59] Southeast Asian ovalocytosis: D58.1: 9416
Refractory anemia with ring sideroblasts is a type of myelodysplastic syndrome. RARS is characterized by 5% or less myeloblasts in bone marrow. RARS is distinguished from refractory anemia by having 15% or more ringed sideroblasts among the erythroid precursors in the bone marrow. [1]
Basophilic is a technical term used by pathologists. It describes the appearance of cells , tissues and cellular structures as seen through the microscope after a histological section has been stained with a basic dye .
A Howell–Jolly body is a cytopathological finding of basophilic nuclear remnants (clusters of DNA) in circulating erythrocytes. During maturation in the bone marrow, late erythroblasts normally expel their nuclei; but, in some cases, a small portion of DNA remains. The presence of Howell–Jolly bodies usually signifies a damaged or absent ...
In optical microscopy these cells appear to have a dark center (a central, hemoglobinized area) surrounded by a white ring (an area of relative pallor), followed by dark outer (peripheral) second ring containing a band of hemoglobin. However, in electron microscopy they appear very thin and bell shaped (hence the name codo-: bell).