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A number of ototoxic medications can damage your ear structures by disrupting the delicate chemical balance of your inner ear or killing hair cells responsible for hearing, says Palmer.
Hair cells are only regenerated after damage. [21] Hair cells in chicks are regenerated just three days after damage is inflicted, and the hair cells fully recover within 30 days. [22] Supporting cells begin to replicate and form hair cells within 18–24 hours after damage, and this process peaks in 2–3 days. [23]
Once outer hair cells are damaged, they do not regenerate, and the result is a loss of sensitivity and an abnormally large growth of loudness (known as recruitment) in the part of the spectrum that the damaged cells serve. [13] While hearing loss has always been considered irreversible in mammals, fish and birds routinely repair such damage. A ...
Outer hair cells are found only in mammals. While hearing sensitivity of mammals is similar to that of other classes of vertebrates, without functioning outer hair cells, the sensitivity decreases by approximately 50 dB. [15] Outer hair cells extend the hearing range to about 200 kHz in some marine mammals. [16]
The hair cells are the primary auditory receptor cells and they are also known as auditory sensory cells, acoustic hair cells, auditory cells or cells of Corti. The organ of Corti is lined with a single row of inner hair cells and three rows of outer hair cells. The hair cells have a hair bundle at the apical surface of the cell.
Structural damage to hair cells (primarily the outer hair cells) will result in hearing loss that can be characterized by an attenuation and distortion of incoming auditory stimuli. During hair cell death 'scars' develop, which prevent potassium rich fluid of the endolymph from mixing with the fluid on the basal domain. [86]
[5] [6] Furthermore, Hensen's cells are also able to regenerate the damaged hair cells in some vertebrates; they undergo phagocytosis to eject the dead or injured hair cells, and reproduce both new hair cells and supporting cells into the cell cycle. One of the reasons is that the supporting cells are differentiated by the embryonic hair cells ...
Stereocilia (along with the entirety of the hair cell) in mammals can be damaged or destroyed by excessive loud noises, disease, medications, as well as toxins and are not regenerable. [ 3 ] [ 11 ] Environmental noise induced hearing impairment is probably the most prevalent noise health effect according to the U.S. Environmental Protection ...