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Actin is a family of globular multi-functional proteins that form microfilaments in the cytoskeleton, and the thin filaments in muscle fibrils.It is found in essentially all eukaryotic cells, where it may be present at a concentration of over 100 μM; its mass is roughly 42 kDa, with a diameter of 4 to 7 nm.
In both cases, F-actin is enriched around the cell periphery. Scale bar: 10 micrometers. The cell cortex, also known as the actin cortex, cortical cytoskeleton or actomyosin cortex, is a specialized layer of cytoplasmic proteins on the inner face of the cell membrane. It functions as a modulator of membrane behavior and cell surface properties.
Actin, alpha skeletal muscle is a protein that in humans is encoded by the ACTA1 gene. [5] [6] Actin alpha 1 which is expressed in skeletal muscle is one of six different actin isoforms which have been identified. Actins are highly conserved proteins that are involved in cell motility, structure and integrity.
In non-muscle cells, it is found by the actin filaments and at the adhesion sites. [1] The lattice like arrangement provides stability to the muscle contractile apparatus. [1] Specifically, it helps bind actin filaments to the cell membrane. [2] There is a binding site at each end of the rod and with bundles of actin filaments. [1]
Actin, cytoplasmic 2, or gamma-actin is a protein that in humans is encoded by the ACTG1 gene. [5] Gamma-actin is widely expressed in cellular cytoskeletons of many tissues; in adult striated muscle cells, gamma-actin is localized to Z-discs and costamere structures, which are responsible for force transduction and transmission in muscle cells.
Actin beta (HUGO Gene Nomenclature Committee abbreviation ACTB/ACTB) is one of six different actin isoforms which have been identified in humans. This is one of the two nonmuscle cytoskeletal actins. Actins are highly conserved proteins [5] [6] that are involved in cell motility, structure and integrity. Alpha actins are a major constituent of ...
59 11475 Ensembl ENSG00000107796 ENSMUSG00000035783 UniProt P62736 P62737 RefSeq (mRNA) NM_001141945 NM_001613 NM_001320855 NM_007392 RefSeq (protein) NP_001135417 NP_001307784 NP_001604 NP_031418 Location (UCSC) Chr 10: 88.94 – 88.99 Mb Chr 19: 34.22 – 34.23 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse ACTA2 (actin alpha 2) is an actin protein with several aliases including ...
Alpha-actinin-2 is a 103.8 kDa protein composed of 894 amino acids. [6] [7] Each molecule is rod-shaped (35 nm in length) and it homodimerizes in an anti-parallel fashion.. Each monomer has an N-terminal actin-binding region composed of two calponin homology domains, two C-terminal EF hand domains, and four tandem spectrin-like repeats form the rod domain in the central region of the molecule.