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Aging is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death. The hallmarks of aging are the types of biochemical changes that occur in all organisms that experience biological aging and lead to a progressive loss of physiological integrity, impaired function and, eventually, death.
Ideally, biomarkers of aging should assay the biological process of aging and not a predisposition to disease, should cause a minimal amount of trauma to assay in the organism, and should be reproducibly measurable during a short interval compared to the lifespan of the organism. [1]
This is an accepted version of this page This is the latest accepted revision, reviewed on 2 February 2025. Biological process of getting older This article is about ageing specifically in humans. For the ageing of whole organisms including animals, see Senescence. For other uses, see Ageing (disambiguation). Part of a series on Human growth and development Stages Gamete Zygote Embryo Fetus ...
Ageing Research Reviews is a peer-reviewed scientific journal publishing review articles covering research on ageing, aging-associated diseases, and human life expectancy. The editor-in-chief is Claudio Franceschi ( University of Bologna ).
Natural selection is a process that allows organisms to better adapt to the environment, it is the survival of the fittest which are predicted to produce more offsprings. Natural selection acts on life history traits in order to optimize reproductive success and lifetime fitness.
Cohorts for Heart and Aging Research in Genomic Epidemiology, abbreviated CHARGE, is a consortium formed to facilitate meta-analyses of genome-wide association studies of aging and cardiovascular traits, and the replication of genotype–phenotype associations identified in such studies.
The authors begin by seeking to characterize how professionals view the hallmarks of aging, including genomic instability caused by DNA damage; alterations to the epigenome that controls which genes are turned on and off; loss of healthy protein maintenance, known as proteostasis; exhaustion of stem cells; and the production of inflammatory ...
Aubrey David Nicholas Jasper de Grey (/ d ə ˈ ɡ r eɪ /; born 20 April 1963) is an English biomedical gerontologist.He is the author of The Mitochondrial Free Radical Theory of Aging (1999) and co-author of Ending Aging (2007).