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A microfibril is a very fine fibril, or fiber-like strand, consisting of glycoproteins and cellulose.It is usually, but not always, used as a general term in describing the structure of protein fiber, e.g. hair and sperm tail.
Cellulose chains are observed to align in overlapping parallel arrays, with the similar polarity forming a cellulose microfibril. In plants, these cellulose microfibrils arrange themselves into layers, formally known as lamellae, and are stabilized in the cell wall by surface, long cross-linking glycan molecules. Glycan molecules increase the ...
Fibrillin-1 is a major component of the microfibrils that form a sheath surrounding the amorphous elastin.It is believed that the microfibrils are composed of end-to-end polymers of fibrillin.
2200 14118 Ensembl ENSG00000166147 ENSMUSG00000027204 UniProt P35555 Q61554 RefSeq (mRNA) NM_000138 NM_007993 RefSeq (protein) NP_000129 NP_032019 Location (UCSC) Chr 15: 48.41 – 48.65 Mb Chr 2: 125.14 – 125.35 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Fibrillin-1 is a protein that in humans is encoded by the FBN1 gene, located on chromosome 15. It is a large, extracellular ...
It lacks a hydrophobic carboxyl terminus and proline-, glutamine-, and tyrosine-rich regions, which are characteristics of a related 31-kDa microfibril-associated glycoprotein (MFAP2). The close similarity between these two proteins is confined to a central region of 60 aa where precise alignment of 7 cysteine residues occurs.
Cellulose microfibrils are made on the surface of cell membranes to reinforce cells walls, which has been researched extensively by plant biochemists and cell biologist because 1) they regulate cellular morphogenesis and 2) they serve alongside many other constituents (i.e. lignin, hemicellulose, pectin) in the cell wall as a strong structural support and cell shape. [15]
The direction of the microfibrils is called microfibril angle (MFA). In the secondary cell wall of fibres of trees a low microfibril angle is found in the S2-layer, while S1 and S3-layers show a higher MFA . However, the MFA can also change depending on the loads on the tissue. It has been shown that in reaction wood the MFA in S2-layer can ...
Microfibrillar-associated protein 2 is a protein that in humans is encoded by the MFAP2 gene. [5] [6]Microfibrillar-associated protein 2 is a major antigen of elastin-associated microfibrils and a candidate for involvement in the etiology of inherited connective tissue diseases.