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Apremilast, sold under the brand name Otezla among others, is a medication for the treatment of certain types of psoriasis and psoriatic arthritis. [4] The drug acts as a selective inhibitor of the enzyme phosphodiesterase 4 (PDE4). [ 4 ]
Apremilast, a phthalimide derivative that was approved by the U.S. FDA in March 2014 for use as a treatment for psoriatic arthritis, [21] and in September 2014 for the treatment of plaque psoriasis under the brand name Otezla.
GLP-1 drugs do a lot more than just help you lose weight. They can help your heart, brain, and more, but beware what they might do to muscle and skin. The Terrible—and Amazing—Side Effects of ...
The term non-steroidal, common from around 1960, distinguishes these drugs from corticosteroids, another class of anti-inflammatory drugs, [7] which during the 1950s had acquired a bad reputation due to overuse and side-effect problems after their introduction in 1948. [8] [9] [10]
Psoriatic arthritis (PsA) is a long-term inflammatory arthritis that occurs in people affected by the autoimmune disease psoriasis. [1] [2] The classic features of psoriatic arthritis include dactylitis (sausage-like appearance), skin lesions, and nail lesions. [3]
Apremilast (Otezla, Celgene) is an oral small-molecule inhibitor of the enzyme phosphodiesterase 4, which plays an important role in chronic inflammation associated with psoriasis. [ 110 ] It has been theorized that antistreptococcal medications may improve guttate and chronic plaque psoriasis; however, limited studies do not show that ...
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The effect of grapefruit juice with regard to drug absorption was originally discovered in 1989 by a group led by pharmacologist David Bailey.Their first published clinical report on grapefruit drug interactions was in 1991. [9]
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