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Left untreated, it has a mortality rate of 8% to 58%, with a greater death rate among males. [3] The symptoms of syphilis have become less severe over the 19th and 20th centuries, in part due to widespread availability of effective treatment, and partly due to virulence of the bacteria. [23] With early treatment, few complications result. [22]
Cause of death disputed, but symptoms match to mercury poisoning from syphilis treatment. [10] Robert Schumann (1810–1856), German composer Acquired syphilis from a prostitute in the age of 21. [11] Bram Stoker (1847–1912), Irish author Cause of death listed as "Locomotor ataxia 6 months", presumed to be a reference to syphilis. [12] [13]
Syphilis infections are increasing in the United States. [69] Trichomoniasis is a common STI that is caused by infection with a protozoan parasite called Trichomonas vaginalis. [70] Trichomoniasis affects both women and men, but symptoms are more common in women. [71]
Rates of syphilis in 2000–2005 among low-risk groups such as women without children and unmarried people were about 0.3–0.6% while rates among high-risk groups such as drug users and MSM were about 7–15%. [11] Rates are greatest among men who have sex with men and sex workers. [10]
General paresis, also known as general paralysis of the insane (GPI), paralytic dementia, or syphilitic paresis is a severe neuropsychiatric disorder, classified as an organic mental disorder, and is caused by late-stage syphilis and the chronic meningoencephalitis and cerebral atrophy that are associated with this late stage of the disease when left untreated.
The history of syphilis has been well studied, but the exact origin of the disease was the source of debate until archaeological and genetic evidence showed conclusively it originated in the Americas.
Untreated early syphilis infections results in a high risk of poor pregnancy outcomes, including saddle nose, lower extremity abnormalities, miscarriages, premature births, stillbirths, or death in newborns. Some infants with congenital syphilis have symptoms at birth, but many develop symptoms later.
Neurosyphilis is the infection of the central nervous system by Treponema pallidum, the bacterium that causes the sexually transmitted infection syphilis.In the era of modern antibiotics, the majority of neurosyphilis cases have been reported in HIV-infected patients.