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Hypoxia-inducible factors (HIFs) are transcription factors that respond to decreases in available oxygen in the cellular environment, or hypoxia. [1] [2] They also respond to instances of pseudohypoxia, such as thiamine deficiency. [3] [4] Both hypoxia and pseudohypoxia leads to impairment of adenosine triphosphate (ATP) production by the ...
Silent hypoxia (also known as happy hypoxia) [115] [116] is generalised hypoxia that does not coincide with shortness of breath. [ 117 ] [ 118 ] [ 119 ] This presentation is known to be a complication of COVID-19 , [ 120 ] [ 121 ] and is also known in atypical pneumonia , [ 122 ] altitude sickness, [ 123 ] [ 124 ] [ 125 ] and rebreather ...
Tissue hypoxia refers to low levels of oxygen in the tissues of the body and the term hypoxia is a general term for low levels of oxygen. [2] Hypoxemia is usually caused by pulmonary disease whereas tissue oxygenation requires additionally adequate circulation of blood and perfusion of tissue to meet metabolic demands. [4]
53417 Ensembl ENSG00000124440 ENSMUSG00000004328 UniProt Q9Y2N7 Q0VBL6 RefSeq (mRNA) NM_022462 NM_152794 NM_152795 NM_152796 NM_001162950 NM_016868 RefSeq (protein) NP_071907 NP_690007 NP_690008 NP_690009 NP_001156422 NP_058564 Location (UCSC) Chr 19: 46.3 – 46.34 Mb Chr 7: 16.77 – 16.8 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Hypoxia-inducible factor 3 alpha is a protein ...
Hypoxia-inducible factor 1-alpha, also known as HIF-1-alpha, is a subunit of a heterodimeric transcription factor hypoxia-inducible factor 1 that is encoded by the HIF1A gene. [ 5 ] [ 6 ] [ 7 ] The Nobel Prize in Physiology or Medicine 2019 was awarded for the discovery of HIF.
55662 319594 Ensembl ENSG00000166135 ENSMUSG00000036450 UniProt Q9NWT6 Q8BLR9 RefSeq (mRNA) NM_017902 NM_176958 RefSeq (protein) NP_060372 NP_795932 Location (UCSC) Chr 10: 100.53 – 100.56 Mb Chr 19: 44.55 – 44.56 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Hypoxia-inducible factor 1-alpha inhibitor (FIH) is a protein that in humans is encoded by the HIF1AN gene. Interactions ...
2034 13819 Ensembl ENSG00000116016 ENSMUSG00000024140 UniProt Q99814 P97481 RefSeq (mRNA) NM_001430 NM_010137 RefSeq (protein) NP_001421 NP_034267 Location (UCSC) Chr 2: 46.29 – 46.39 Mb Chr 17: 87.06 – 87.14 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Endothelial PAS domain-containing protein 1 (EPAS1, also known as hypoxia-inducible factor-2alpha (HIF-2α)) is a protein ...
112406 Ensembl ENSG00000269858 ENSMUSG00000058709 UniProt Q96KS0 Q91YE2 RefSeq (mRNA) NM_080732 NM_017555 NM_053046 NM_053208 NM_001357767 RefSeq (protein) NP_444274 NP_542770 NP_444438 NP_001344696 Location (UCSC) Chr 19: 40.8 – 40.81 Mb Chr 7: 26.86 – 26.87 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Egl nine homolog 2 is a protein that in humans is encoded by the EGLN2 ...