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PAI-1's main function entails the inhibition of urokinase plasminogen activator (uPA), an enzyme responsible for the cleavage of plasminogen to form plasmin. Plasmin mediates the degradation of the extracellular matrix either by itself or in conjunction with matrix metalloproteinases.
PA1 or PA-1 may refer to: Pad Abort Test 1, a 1963 Apollo test flight; Pad Abort 1 (Orion), a 2010 Orion test flight; Pennsylvania's 1st congressional district; Pennsylvania state route 1, a former state highway near Philadelphia; U.S. Route 1 in Pennsylvania; Muhammed Akbar Khan, Pakistan Army general; ALCO PA, train locomotive
The PA-1 was a single-seat biplane with N-struts powered by a Wright R-1454 radial engine, an all-wood fuselage and wings with fabric coverings. The USAAS ordered two prototypes.
Pennsylvania's first congressional district includes all of Bucks County and a sliver of Montgomery County in southeastern Pennsylvania.It has been represented by Brian Fitzpatrick since 2019.
Although all four orders contained "A" cars with cabs at one end, the PA1 and PA2 orders also contained some "C" cars. Trains could comprise three to eight cars, but in order to operate, there had to be an even number of "A" cars in the consist, including one "A" car at each end. [209] All PA1-PA4 equipment was retired from passenger service by ...