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The chromosomal location of BRCA1 was discovered by Mary-Claire King's team at UC Berkeley in 1990. [21] After an international race to refine the precise location of BRCA1, [22] the gene was cloned in 1994 by scientists at University of Utah, National Institute of Environmental Health Sciences (NIEHS) and Myriad Genetics.
Inheriting one BRCA1 mutation and one BRCA2 mutation has been reported occasionally; the child's risk for any given type of cancer is the higher risk of the two genes (e.g., the ovarian cancer risk from BRCA1 and the pancreatic cancer risk from BRCA2). Inheriting two BRCA2 mutations produces Fanconi anemia. [9]: 82–85
BRE, the protein product of the BRE (gene), is a core component of the deubiquitin complex BRCA1-A. [8] Other core components of the BRCA1-A complex are the BRCC36 protein (BRCC3 gene), MERIT40 protein (BABAM1 gene), and RAP80 protein (UIMC1 gene). [8]
Decoding Annie Parker is a 2013 American drama film written and directed by Steven Bernstein.The film stars Samantha Morton, Helen Hunt and Aaron Paul.The film tells the story of Annie Parker [1] and the discovery of the BRCA1 breast cancer gene.
Mary-Claire King was born on February 27, 1946, to Harvey and Clarice King of Wilmette, Illinois, near Chicago.Her father worked for Standard Oil of Indiana. [1] When King was 15 years old, her childhood best friend died of cancer.
58202 Ensembl ENSG00000188986 ENSMUSG00000013465 UniProt Q8WX92 Q8C4Y3 RefSeq (mRNA) NM_015456 NM_021393 NM_001310157 RefSeq (protein) NP_056271 NP_001297086 NP_067368 Location (UCSC) Chr 9: 137.26 – 137.27 Mb Chr 2: 25.09 – 25.1 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Cofactor of BRCA1, also known as COBRA1, is a human gene that encodes NELF-B. Function NELF-B is a ...
BRCA1, the first of these genes to be discovered; BRCA2, the second of these genes to be discovered; British Radio Car Association, a British radio controlled car racing organisation; Brotherhood Railway Carmen of America, a defunct American trade union; Bureau Central de Renseignements et d'Action, the Free French intelligence agency during ...
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