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The five main classes in the Vaughan Williams classification of antiarrhythmic agents are: Class I agents interfere with the sodium (Na +) channel. Class II agents are anti-sympathetic nervous system agents. Most agents in this class are beta blockers. Class III agents affect potassium (K +) efflux. Class IV agents affect calcium channels and ...
This is a list of cardiology mnemonics, categorized and alphabetized. For mnemonics in other medical specialities, see this list of medical mnemonics . Aortic regurgitation: causes
1 Antiarrhythmic agents. 2 ACE inhibitors. ... 9 Antiplatelet drug. 10 Anticoagulant. 11 Fibrinolytics. ... and often are not particularly specific to a given class ...
This is a list of mnemonics used in medicine and medical science, categorized and alphabetized. A mnemonic is any technique that assists the human memory with information retention or retrieval by making abstract or impersonal information more accessible and meaningful, and therefore easier to remember; many of them are acronyms or initialisms which reduce a lengthy set of terms to a single ...
Pharmacological cardiotoxicity is defined as cardiac damage that occurs under the action of a drug. This can occur both through damage of cardiac muscle as well as through alteration of the ion currents of cardiomyocytes. [1] Two distinct drug classes in which cardiotoxicity can occur are in anti-cancer and antiarrhythmic drugs.
Prajmaline (Neo-gilurythmal) [1] is a class Ia antiarrhythmic agent [2] which has been available since the 1970s. [3] Class Ia drugs increase the time one action potential lasts in the heart. [ 4 ] Prajmaline is a semi-synthetic propyl derivative of ajmaline , with a higher bioavailability than its predecessor. [ 5 ]
Class Ic antiarrhythmic agents markedly depress the phase 0 depolarization (decreasing V max). They decrease conductivity, but have a minimal effect on the action potential duration. Of the sodium channel blocking antiarrhythmic agents (the class I antiarrhythmic agents), the class Ic agents have the most potent sodium channel blocking effects.
Procainamide (PCA) is a medication of the antiarrhythmic class used for the treatment of cardiac arrhythmias. It is a sodium channel blocker of cardiomyocytes; thus it is classified by the Vaughan Williams classification system as class Ia. In addition to blocking the I Na current, it inhibits the I Kr rectifier K+ current. [1]