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An atypical mole may also be referred to as an atypical melanocytic nevus, [2] atypical nevus, B-K mole, Clark's nevus, dysplastic melanocytic nevus, or nevus with architectural disorder. [ 3 ] Dysplastic nevi often grow to larger than ordinary moles and may have irregular and indistinct borders.
The features include: 1) two or more clinically atypical nevi, 2) more than 100 nevi in patients between 20 and 50 years of age, 3) more than 50 nevi in patients under 20 years of age or more than 50 years of age, 4) more than one nevus in buttocks or instep, 5) nevi on the anterior scalp, 6) one or more pigmented lesions in the iris.
The size of the punch biopsy can vary from 1 mm to 2 mm, but it is preferable to use a punch 1.5 mm or larger. Representative samples of the most atypical parts of the nevus should be biopsied, often guided by dermatoscopy.
Dysplastic nevus syndrome is a largely hereditary condition that causes a person to have a large quantity of moles (often 100 or more), with some larger than normal or atypical. This often leads to a higher risk of melanoma, a serious type of skin cancer. [10] Dysplastic nevi are more likely than ordinary moles to become cancerous.
Spitz nevus is the medical name for a benign mole. They share a similar appearance with other moles, some that are cancerous. Learn more here.
A related category of melanocytic proliferation is superficial atypical melanocytic proliferations of uncertain significance (SAMPUS). This category, unlike MELTUMP, which implies as yet undetermined potential for metastases even after complete excision, signifies lesions without metastatic potential at time of excision but with potential to ...
This is in contrast to the "nests" of multi-layer melanocytes found in moles (melanocytic nevi). Because of this characteristic feature, the adjective "lentiginous" is used to describe other skin lesions that similarly proliferate linearly within the basal cell layer. [1] [2]
Compound: epidermis and dermis; Atypical (dysplastic) nevus: This type of nevus must be diagnosed based on histological features. Clinically, atypical nevi are characterized by variable pigmentation and irregular borders. [5] Becker's nevus; Blue nevus (rarely congenital): A classic blue nevus is usually smaller than 1 cm, flat, and blue-black ...