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Confocal microscopy Z projection of medium spiny neurons (MSNs) in the mouse striatum. The neurons were labeled using the matrisome MSN mouse Gpr101-Cre [8] in combination with a dtTomato (red fluorescent protein) reporter. A 3D projection of the same neurons can be viewed here.
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The mesolimbic pathway and a specific set of the pathway's output neurons (e.g. D1-type medium spiny neurons within the nucleus accumbens) play a central role in the neurobiology of addiction. [ 20 ] [ 21 ] [ 22 ] Drug addiction is an illness caused by habitual substance use that induces chemical changes in the brain's circuitry. [ 23 ]
Projection fibers consist of efferent and afferent fibers uniting the cortex with the lower parts of the brain and with the spinal cord. In human neuroanatomy, bundles of axons (nerve fibers) called nerve tracts , within the brain, can be categorized by their function into association tracts , projection tracts , and commissural tracts .
The output neurons of the nucleus accumbens send axonal projections to the basal ganglia and the ventral analog of the globus pallidus, known as the ventral pallidum (VP). ). The VP, in turn, projects to the medial dorsal nucleus of the dorsal thalamus, which projects to the prefrontal cortex as well as back to the ventral and to dorsal stri
Location: Layer V of cortex in primary motor cortex: Shape: Multipolar pyramidal -- some of the longest axons in the body. Function: Excitatory projection neuron to spinal cord: Neurotransmitter: Glutamate: Presynaptic connections: Superficial cortical layers, premotor cortex: Postsynaptic connections: Ventral horn of the spinal cord ...
Again, adjacent areas on the skin are represented by adjacent neurons in all aforementioned structures. This projection pattern has been termed somatotopy. One common diagram of the somatotopic map is the cortical homunculus. This illustration is a fairly accurate representation of how much cortical area represents each body part or region.
Dendritic spines serve as a storage site for synaptic strength and help transmit electrical signals to the neuron's cell body. Most spines have a bulbous head (the spine head), and a thin neck that connects the head of the spine to the shaft of the dendrite. The dendrites of a single neuron can contain hundreds to thousands of spines.