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NADPH is used as a reducing agent in many anabolic reactions. Proton translocating NAD(P) + transhydrogenase is one of the main ways that cells can regenerate NADPH after it is used. In E. coli, this pathway contribute equal amounts of NADPH as the pentose phosphate pathway, and both were the main producers of NADPH under standard growth ...
an alcohol + NAD(P) + an aldehyde + NAD(P)H + H + The 3 substrates of this enzyme are alcohol , NAD + , and NADP + , whereas its 4 products are aldehyde , NADH , NADPH , and H + . This enzyme belongs to the family of oxidoreductases , specifically those acting on the CH-OH group of donor with NAD + or NADP + as acceptor.
Transhydrogenase may stand for NAD(P)+ transhydrogenase (Re/Si-specific) NAD(P)+ transhydrogenase (Si-specific) Proton-Translocating NAD(P)+ Transhydrogenase; Hydroxyacid-oxoacid transhydrogenase; Glutathione—cystine transhydrogenase; Lactate—malate transhydrogenase; Glutathione—homocystine transhydrogenase; Glutathione—CoA-glutathione ...
In biochemistry, NAD(P) + transhydrogenase (Si-specific) (EC 1.6.1.1) is an enzyme that catalyzes the chemical reaction. NADPH + NAD + NADP + + NADH. Thus, the two substrates of this enzyme are NADPH and NAD +, whereas its two products are NADP + and NADH. This enzyme participates in nicotinate and nicotinamide metabolism.
The zinc coordinates the substrate (alcohol). The zinc is coordinated by Cys-46, Cys-174, and His-67. Leu-319, Ala-317, His-51, Ile-269 and Val-292 stabilize NAD + by forming hydrogen bonds. His-51 and Ile-269 form hydrogen bonds with the alcohols on nicotinamide ribose. Phe-319, Ala-317 and Val-292 form hydrogen bonds with the amide on NAD +. [27]
NAD(P)+ transhydrogenase (Si-specific) This page was last edited on 28 May 2015, at 13:20 (UTC). Text is available under the Creative Commons Attribution ...
Nicotinamide adenine dinucleotide phosphate, abbreviated NADP [1] [2] or, in older notation, TPN (triphosphopyridine nucleotide), is a cofactor used in anabolic reactions, such as the Calvin cycle and lipid and nucleic acid syntheses, which require NADPH as a reducing agent ('hydrogen source').
NAD(P) transhydrogenase, mitochondrial is an enzyme that in humans is encoded by the NNT gene on chromosome 5. [ 5 ] [ 6 ] [ 7 ] The NNT gene contains 26 exons and encodes a transhydrogenase protein that is ~109 kDa in molecular weight and is involved in antioxidant defense in the mitochondria .