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A Michael reaction is used as a mechanistic step by many covalent inhibitor drugs. Cancer drugs such as ibrutinib, osimertinib, and rociletinib have an acrylamide functional group as a Michael acceptor. The Michael donor on the drug reacts with a Michael acceptor in the active site of an enzyme. This is a viable cancer treatment because the ...
NEM is a Michael acceptor in the Michael reaction, which means that it adds nucleophiles such as thiols. The resulting thioether features a strong C–S bond and the reaction is virtually irreversible. Reaction with thiols occur in the pH range 6.5–7.5, NEM may react with amines or undergo hydrolysis at a more alkaline pH.
The Stork enamine alkylation involves the addition of an enamine to a Michael acceptor (e.g., an α,β -unsaturated carbonyl compound) or another electrophilic alkylation reagent to give an alkylated iminium product, which is hydrolyzed by dilute aqueous acid to give the alkylated ketone or aldehyde. [1]
In the Michael reaction, the ketone is deprotonated by a base to form an enolate nucleophile which attacks the electron acceptor (in red). This acceptor is generally an α,β-unsaturated ketone, although aldehydes, acid derivatives and similar compounds can work as well (see scope). In the example shown here, regioselectivity is dictated by the ...
In addition to standard nucleophilic addition reactions on the C=C bond, nitroethylene can serve as a Michael acceptor in a Michael addition reaction. A typical Michael donor (i.e. ketone or aldehyde) can be used. [8] Like most nitro compounds, a platinum/palladium catalyzed reaction with hydrogen gas can reduce the nitro group to an amine group.
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Turns out J.Lo and Ben “have a mutual respect for one another” and that's “not something that goes away” quickly. As the insider put it, “Obviously things haven’t been the same, but ...
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