Search results
Results From The WOW.Com Content Network
In general, mutations resulting in antimicrobial resistance alter the antibiotic action via one of the following mechanisms, i) modifications of the antimicrobial target (decreasing the affinity for the drug, see below), i) a decrease in the drug uptake, ii) activation of efflux mechanisms to extrude the harmful molecule, or iv) global changes ...
antibiotic resistance, loss of susceptibility of bacteria to the killing (bacteriocidal) or growth-inhibiting (bacteriostatic) properties of an antibiotic agent. When a resistant strain of bacteria is the dominant strain in an infection, the infection may be untreatable and life-threatening.
In this chapter, we will describe in detail the major mechanisms of antibiotic resistance encountered in clinical practice, providing specific examples in relevant bacterial pathogens.
Understanding the molecular mechanisms that bacteria use to resist the action of antimicrobials is critical to recognize global patterns of resistance and to improve the use of current...
As described above, gene amplifications can lead to antibiotic resistance via diverse mechanisms (Fig. 4, Table 1), and fitness costs associated with gene amplifications can be ameliorated by the ...
The study of bacterial defences can inform current and future antibacterial therapeutics. Origins of drug resistance. Understanding where resistance genes come from can help to predict and ...
This review delves into the specific mechanisms that bacteria have developed to resist antibiotics, with the help of diagrammatic illustrations. Antibiotic resistance can spread among bacteria through various routes, resulting in previously susceptible bacteria becoming antibiotic-resistant.
Mechanisms of antibiotic resistance in bacteria. Bacterial cell membrane barriers and membrane protein can prevent antibiotics uptake, or bacteria can reduce intracellular concentration by efflux pumps. Also, antibiotic targets can be modified to reduce affinity. Finally, some antibiotics can be deactivated by specialized enzymes like β ...
(A) Antibiotic resistance is evidenced through five general mechanisms: (A) Decreased permeability: the physical-chemical barriers provided by the outer membrane and metabolite-gating porins allow for controlled entry of molecules into the cell, preventing penetration of antibiotics.
The mechanism of antibiotic resistance is commonly categorized into the following four groups: Intrinsic Resistance: Bacteria might survive an antibiotic due to intrinsic resistance through evolution by changing their structure or components.