Search results
Results From The WOW.Com Content Network
Otto Warburg postulated this change in metabolism is the fundamental cause of cancer, [8] a claim now known as the Warburg hypothesis. Today, mutations in oncogenes and tumor suppressor genes are thought to be responsible for malignant transformation, and the Warburg effect is considered to be a result of these mutations rather than a cause. [9 ...
The inversion to the Warburg effect is a corollary to the Warburg hypothesis or Warburg effect that was discovered in obesity. Warburg's hypothesis suggests that tumor cells proliferate quickly and aggressively by obtaining energy or ATP, through high glucose consumption and lactate production. [1]
Scientist Otto Warburg, whose research activities led to the formulation of the Warburg hypothesis for explaining the root cause of cancer.. The Warburg hypothesis (/ ˈ v ɑːr b ʊər ɡ /), sometimes known as the Warburg theory of cancer, postulates that the driver of carcinogenesis (cancer formation) is insufficient cellular respiration caused by insult (damage) to mitochondria. [1]
The Warburg effect, named for Otto Heinrich Warburg, may refer to: Warburg effect (embryology) Warburg effect inversion; Warburg effect (oncology)
In fact, the low ATP:ADP ratio caused by this effect likely contributes to the deactivation of mitochondria. Mitochondrial membrane potential is hyperpolarized to prevent voltage-sensitive permeability transition pores (PTP) from triggering of apoptosis. [27] [28] There are many works that sustain that cancer is a metabolic disease.
Therefore, the classical explanation fails to reason why lactate must be transported to liver or mitochondria for effective recycling. Murburn concept reasons out such conundrums and also affords a new approach for understanding Warburg effect and therapy of cancer. [47] Origin and evolution of life
More generally, in the medical literature, the Pasteur effect refers to how the cellular presence of oxygen causes in cells a decrease in the rate of glycolysis and also a suppression of lactate accumulation. The effect occurs in animal tissues, as well as in microorganisms belonging to the fungal kingdom. [2] [3]
The Warburg coefficient has units of / = / The value of A W can be obtained by the gradient of the Warburg plot, a linear plot of the real impedance (R) against the reciprocal of the square root of the frequency (/). This relation should always yield a straight line, as it is unique for a Warburg.