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Cell potency is a cell's ability to differentiate into other cell types. [1] [2] The more cell types a cell can differentiate into, the greater its potency.Potency is also described as the gene activation potential within a cell, which like a continuum, begins with totipotency to designate a cell with the most differentiation potential, pluripotency, multipotency, oligopotency, and finally ...
The liver receptor homolog-1 (LRH-1) also known as totipotency pioneer factor NR5A2 (nuclear receptor subfamily 5, group A, member 2) is a protein that in humans is encoded by the NR5A2 gene. [ 5 ] [ 6 ] LRH-1 is a member of the nuclear receptor family of intracellular transcription factors .
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During somatic cell nuclear transfer, the oocyte turns off tissue specific genes in the somatic cell nucleus and turns back on embryonic specific genes. This process has been shown through cloning, as seen through John Gurdon with the tadpoles [27] and Dolly the Sheep. [39] Notably, these events have shown that cell fate is a reversible process.
Three basic categories of cells make up the mammalian body: germ cells, somatic cells, and stem cells.Each of the approximately 37.2 trillion (3.72x10 13) cells in an adult human has its own copy or copies of the genome except certain cell types, such as red blood cells, that lack nuclei in their fully differentiated state.
The main goal of biochemical cascades in lymphocytes is the secretion of molecules that can suppress altered cells or eliminate pathogenic agents, through proliferation, differentiation and activation of these cells. Therefore, the antigenic receptors play a central role in signal transduction in lymphocytes, because when antigens interact with ...
In humans with non-injured tissues, the tissue naturally regenerates over time; by default, new available cells replace expended cells. For example, the body regenerates a full bone within ten years, while non-injured skin tissue is regenerated within two weeks. [2] With injured tissue, the body usually has a different response.
His original idea presented in 1902 was called totipotentiality (now termed as totipotency): “Theoretically all plant cells are able to give rise to a complete plant.” [3] [4] [5] In his 1905 work "Die lichtsinnesorgane der laubblätter" Haberlandt suggested that plants might be able to see using organs on the upper surface of the leaf. [6] [7]