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Barry John Durrant-Peatfield (November 1936 – 27 August 2023) was a British medical practitioner specialising in metabolic disorders namely, hypothyroidism.. Durrant-Peatfield submitted to voluntary erasure from the medical register as an alternative to having his license suspended for the use of unapproved diagnostic tests and treatments such as whole thyroid extracts (NDT).
Thyroid disease is a medical condition that affects the structure and/or function of the thyroid gland. The thyroid gland is located at the front of the neck and produces thyroid hormones [1] that travel through the blood to help regulate many other organs, meaning that it is an endocrine organ. These hormones normally act in the body to ...
Organification is a biochemical process that takes place in the thyroid gland. It is the incorporation of iodine into thyroglobulin for the production of thyroid hormone, a step done after the oxidation of iodide by the enzyme thyroid peroxidase (TPO) [1] Since iodine is an inorganic compound, and is being attached to thyroglobulin, a protein, the process is termed as "organification of iodine".
Administering the radioactive isotope causes the thyroid to take in the lethal iodine and quickly radiation destroys it. [12] Typically overproduction of thyroxine using radio-iodine is blocked with one dose. The drawback to this treatment is the thyroid gland is completely destroyed and patients often develop hypothyroidism. Some do so only a ...
This causes the production of thyroid hormones and subsequent growth and vascularisation of the thyroid. [1] TRAbs are also useful in the diagnosis of Graves' ophthalmopathy . Although the exact mechanism of how TRAbs induce Graves' ophthalmopathy is unknown, it is likely that the antibodies bind to TSH receptors in retro-orbital tissues ...
Created Date: 8/30/2012 4:52:52 PM
Low-T3 syndrome and high-T3 syndrome: Consequences of step-up hypodeiodination, e.g. in critical illness as an example for type 1 allostasis, [20] or hyperdeiodination, as in type 2 allostasis, including posttraumatic stress disorder. [12] Resistance to thyroid hormone: Feedback loop interrupted on the level of pituitary thyroid hormone receptors.
The Wolff–Chaikoff effect is known as an autoregulatory phenomenon that inhibits organification in the thyroid gland, the formation of thyroid hormones inside the thyroid follicle, and the release of thyroid hormones into the bloodstream. [6] This becomes evident secondary to elevated levels of circulating iodide.