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It was discovered in 2000 as one of two improved mutants by H. Bujard and his colleagues after random mutagenesis of the Tet repressor part of the transactivator gene. [6] Tet-On 3G (also known as rtTA-V10 [7]) is similar to Tet-On Advanced but was derived from rtTA2 S-S2 rather than rtTA2 S-M2. It is also human codon optimized and composed of ...
The transactivator gene expresses a transcription factor that binds to specific promoter region of DNA. By binding to the promoter region of a gene, the transcription factor causes that gene to be expressed. The expression of one transactivator gene can activate multiple genes, as long as they have the same, specific promoter region attached.
Thus TET enzymes largely initiate demethylation at 5mCpG sites. Oxoguanine glycosylase (OGG1) is one example of a protein that recruits a TET enzyme. TET1 is able to act on 5mCpG if an ROS has first acted on the guanine to form 8-hydroxy-2'-deoxyguanosine (8-OHdG or its tautomer 8-oxo-dG), resulting in a 5mCp-8-OHdG dinucleotide (see Figure). [10]
Ten-eleven translocation methylcytosine dioxygenase 1 (TET1) is a member of the TET family of enzymes, in humans it is encoded by the TET1 gene.Its function, regulation, and utilizable pathways remain a matter of current research while it seems to be involved in DNA demethylation and therefore gene regulation, [5] [6] but is expressed as different isoforms which may have distinct functions.
[2] [3] Binding of the activator-coactivator complex increases the speed of transcription by recruiting general transcription machinery to the promoter, therefore increasing gene expression. [ 3 ] [ 4 ] [ 5 ] The use of activators and coactivators allows for highly specific expression of certain genes depending on cell type and developmental stage.
17684 Ensembl ENSG00000164442 ENSMUSG00000039910 UniProt Q99967 O35740 RefSeq (mRNA) NM_006079 NM_001168388 NM_001168389 NM_010828 RefSeq (protein) NP_001161860 NP_001161861 NP_006070 NP_034958 Location (UCSC) Chr 6: 139.37 – 139.37 Mb Chr 10: 17.6 – 17.6 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Cbp/p300-interacting transactivator 2 is a protein that in humans is encoded ...
TET2 is mutated in 7%–23% of acute myeloid leukemia (AML) patients. [36] Importantly, TET2 is mutated in a mutually exclusive manner with WT1, IDH1, and IDH2. [37] [38] TET2 can be recruited by WT1, a sequence-specific zinc finger transcription factor, to WT1-target genes, which it then activates by converting methylcytosine into 5-hydroxymethylcytosine at the genes’ promoters. [38]
Telomerase reverse transcriptase (abbreviated to TERT, or hTERT in humans) is a catalytic subunit of the enzyme telomerase, which, together with the telomerase RNA component (TERC), comprises the most important unit of the telomerase complex. [5] [6] Telomerases are part of a distinct subgroup of RNA-dependent polymerases.