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Histiocytes are derived from the bone marrow by multiplication from a stem cell. The derived cells migrate from the bone marrow to the blood as monocytes . They circulate through the body and enter various organs, where they undergo differentiation into histiocytes, which are part of the mononuclear phagocytic system (MPS).
Multinucleated giant cells due to an infection. H&E stain.. A giant cell (also known as a multinucleated giant cell, or multinucleate giant cell) is a mass formed by the union of several distinct cells (usually histiocytes), often forming a granuloma.
In medicine, histiocytosis is an excessive number of histiocytes [1] (tissue macrophages), and the term is also often used to refer to a group of rare diseases which share this sign as a characteristic. Occasionally and confusingly, the term histiocytosis is sometimes used to refer to individual diseases.
Macrophages are diffusely scattered in the connective tissue and in liver (Kupffer cells), spleen and lymph nodes (sinus histiocytes), lungs (alveolar macrophages), and central nervous system (microglia). The half-life of blood monocytes is about 1 day, whereas the life span of tissue macrophages is several months or years.
Malignant histiocytosis is a rare hereditary disease found in the Bernese Mountain Dog and humans, characterized by histiocytic infiltration of the lungs and lymph nodes. The liver, spleen, and central nervous system can also be affected. Histiocytes are a component of the immune system that proliferate abnormally in this disease. In addition ...
CD163 (Cluster of Differentiation 163) is a protein that in humans is encoded by the CD163 gene. [5] CD163 is the high affinity scavenger receptor for the hemoglobin-haptoglobin complex [6] and in the absence of haptoglobin - with lower affinity - for hemoglobin alone. [7] It also is a marker of cells from the monocyte/macrophage lineage. [8]
Histoplasma capsulatum is a species of dimorphic fungus.Its sexual form is called Ajellomyces capsulatus.It can cause pulmonary and disseminated histoplasmosis.. Histoplasma capsulatum is "distributed worldwide, except in Antarctica, but most often associated with river valleys" [1] and occurs chiefly in the "Central and Eastern United States" [2] followed by "Central and South America, and ...
A histiocytoma is a tumour consisting of histiocytes. [1] Histiocytes are cells that are a part of the mononuclear phagocytic system, a part of the body's immune system that consists of phagocytic cells, which are responsible for engulfing solid particles by the cell membrane to form an internal phagosome by phagocytes and protists.