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Nikolsky's sign is a clinical dermatological sign, named after Pyotr Nikolsky (1858–1940), a Russian physician who trained and worked in the Russian Empire. The sign is present when slight rubbing of the skin results in exfoliation of the outermost layer.
SSSS is a clinical diagnosis. This is sometimes confirmed by isolation of S. aureus from blood, mucous membranes, or skin biopsy; however, these are often negative. Skin biopsy may show separation of the superficial layer of the epidermis (intraepidermal separation), differentiating SSSS from TEN, wherein the separation occurs at the dermo-epidermal junction (subepidermal separation).
[2] [3] It is seen along with Nikolsky's sign, both used to assess the severity of some blistering diseases such as pemphigus vulgaris and severe bullous drug reactions. [ 4 ] This sign is named for the Danish physician Gustav Asboe-Hansen (1917–1989), who first described it in 1960.
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First, Cole suggests looking inward in a non-pressure situation. "You need to understand why you are the way you are," Cole explains. "You need to want to change.
Nikolsky's sign (gentle lateral pressure) on unaffected mucosa or skin raises a bulla. If no lesions are present on examination it may be useful way of demonstrating reduced epithelial adhesion. If no lesions are present on examination it may be useful way of demonstrating reduced epithelial adhesion.
Hints and the solution for today's Wordle on Tuesday, January 21.