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Sertraline, sold under the brand name Zoloft among others, is an antidepressant medication of the selective serotonin reuptake inhibitor (SSRI) class [10] used to treat major depressive disorder, generalized anxiety disorder, social anxiety disorder, obsessive–compulsive disorder (OCD), panic disorder, and premenstrual dysphoric disorder. [11]
In addition to their actions as reuptake inhibitors of serotonin, some SSRIs are also, coincidentally, ligands of the sigma receptors. [187] [188] Fluvoxamine is an agonist of the σ 1 receptor, while sertraline is an antagonist of the σ 1 receptor, and paroxetine does not significantly interact with the σ 1 receptor.
Sertraline is an FDA-approved medication that belongs to a class of drugs known as selective serotonin reuptake inhibitors, or SSRIs. Sertraline is approved to treat a variety of conditions ...
Serotonin. A serotonin reuptake inhibitor (SRI) is a type of drug which acts as a reuptake inhibitor of the neurotransmitter serotonin (5-hydroxytryptamine, or 5-HT) by blocking the action of the serotonin transporter (SERT). This in turn leads to increased extracellular concentrations of serotonin and, therefore, an increase in serotonergic ...
Antidepressants. Benzodiazepines. Beta-blockers. Other medications, like buspirone. ... Selective Serotonin Reuptake Inhibitors (SSRIs) Selective serotonin reuptake inhibitors, or SSRIs, are one ...
Serotonin-norepinephrine reuptake inhibitors (SNRIs). Another common type of antidepressant, SNRIs work in a similar way to SSRIs by increasing both serotonin and another neurotransmitter called ...
Serotonin antagonist and reuptake inhibitors (SARIs) are a class of drugs used mainly as antidepressants, but also as anxiolytics and hypnotics. They act by antagonizing serotonin receptors such as 5-HT 2A and inhibiting the reuptake of serotonin , norepinephrine , and/or dopamine .
SSRIs (selective serotonin reuptake inhibitors), which debuted in the 1980s, work on serotonin. SNRIs (serotonin and norepinephrine reuptake inhibitors) hit serotonin and norepinephrine.