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Gemcitabine is in the nucleoside analog family of medication. [3] It works by blocking the creation of new DNA, which results in cell death. [3] Gemcitabine was patented in 1983 and was approved for medical use in 1995. [7] Generic versions were introduced in Europe in 2009 and in the US in 2010. [8] [9] It is on the WHO Model List of Essential ...
A full alphabetical listing is included after the categorical listing. The agents in this list are often combined into chemotherapy agent for polychemotherapy (combination chemotherapy). For example, the CHOP regimen consists of cyclophosphamide , doxorubicin , vincristine and prednisone .
Therefore, any DNA strand normally has one end at which there is a phosphate group attached to the 5′ carbon of a ribose (the 5′ phosphoryl) and another end at which there is a free hydroxyl group attached to the 3′ carbon of a ribose (the 3′ hydroxyl).
Azacitidine is a chemical analogue of the nucleoside cytidine, which is present in DNA and RNA.It is thought to have antineoplastic activity via two mechanisms – at low doses, by inhibiting of DNA methyltransferase, causing hypomethylation of DNA, [16] and at high doses, by its direct cytotoxicity to abnormal hematopoietic cells in the bone marrow through its incorporation into DNA and RNA ...
This prevents DNA replication and transcription, causes DNA strand breaks, and leads to programmed cell death . These agents include etoposide , doxorubicin , mitoxantrone and teniposide . The second group, catalytic inhibitors, are drugs that block the activity of topoisomerase II, and therefore prevent DNA synthesis and translation because ...
GVD is a chemotherapy regimen, used for salvage treatment of relapsed or refractory Hodgkin disease, including those patients who relapse after stem cell transplantation. [1]
A chemotherapy regimen is a regimen for chemotherapy, defining the drugs to be used, their dosage, the frequency and duration of treatments, and other considerations.In modern oncology, many regimens combine several chemotherapy drugs in combination chemotherapy.
ReGenesis is a Canadian science-fiction television series produced by The Movie Network and Movie Central in conjunction with Shaftesbury Films.The series, which ran for four seasons from 2004 to 2008, revolves around the scientists of NorBAC (North American Biotechnology Advisory Commission), a fictional organization with a lab based in the city of Toronto.