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In the brain, serotonin is a neurotransmitter and regulates arousal, behavior, sleep, and mood, among other things. [9] During prolonged exercise where central nervous system fatigue is present, serotonin levels in the brain are higher than normal physiological conditions; these higher levels can increase perceptions of effort and peripheral muscle fatigue. [9]
Low serotonin levels have been linked to many physical and psychological symptoms, according to Healthline. However, scientists are unsure what actually causes serotonin deficiency.
Stress, either severe, acute stress or chronic low-grade stress may induce abnormalities in three principal regulatory systems in the body: serotonin systems, catecholamine systems, and the hypothalamic-pituitary-adrenocortical axis. Aggressive behavior has also been associated with abnormalities in these systems. [37]
Serotonin (/ ˌ s ɛr ə ˈ t oʊ n ɪ n, ˌ s ɪər ə-/) [6] [7] [8] or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter.Its biological function is complex, touching on diverse functions including mood, cognition, reward, learning, memory, and numerous physiological processes such as vomiting and vasoconstriction.
NHS figures show that the number of people in England taking antidepressants continues to rise, with 8.3m patients receiving them in 2021/22.
This feel-good hormone plays a key role in everything from sleep and digestion to happiness and contentment—here's how to keep it flowin'.
This experimental approach reduces the availability of tryptophan, an amino acid which serves as the precursor to serotonin. [ 1 ] [ 2 ] The lack of mood-lowering effects after ATD in healthy subjects seems to contradict a direct causal relationship between acutely decreased serotonin levels and depression.
A serotonin pathway identifies aggregate projections from neurons which synthesize and communicate the monoamine neurotransmitter serotonin. [ citation needed ] These pathways are relevant to different psychiatric and neurological disorders.