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2. Discovery and development of direct Xa inhibitors - Wikipedia

   en.wikipedia.org/wiki/Discovery_and_development...

   Rivaroxaban (Xarelto) was the first approved FXa inhibitor to become commercially available in Europe and Canada in 2008. [1] The second one was apixaban (Eliquis), approved in Europe in 2011 [2] and in the United States in 2012. [3] The third one edoxaban (Lixiana, Savaysa) was approved in Japan in 2011 and in Europe and the US in 2015. [4]

3. Rivaroxaban - Wikipedia

   en.wikipedia.org/wiki/Rivaroxaban

   Rivaroxaban, sold under the brand name Xarelto among others, is an anticoagulant medication (blood thinner) used to treat and prevent blood clots. [8] Specifically it is used to treat deep vein thrombosis and pulmonary emboli and prevent blood clots in atrial fibrillation and following hip or knee surgery. [ 8 ]

4. Direct factor Xa inhibitors - Wikipedia

   en.wikipedia.org/wiki/Direct_factor_Xa_inhibitors

   The monitoring of warfarin and keeping the international normalized ratio (INR) between 2.0 and 3.0, along with avoiding over and under treatment, has driven a search for an alternative. [3] [14] A naturally occurring inhibitor of factor Xa was reported in 1971 by Spellman et al. from the dog hookworm. [15]

5. The Big Challenges Seniors Face in Everyday Life - AOL

   www.aol.com/big-challenges-seniors-face-everyday...

   Fitness is important at any age, and the U.S. Department of Health and Human Services urges seniors to stay active as they get older, offering tips that seniors can tailor to their own capabilities.

6. Intimacy After 70: How to Keep Things Lively in the Bedroom ...

   www.aol.com/intimacy-70-keep-things-lively...

   Provided you’re in good-ish health, you can enjoy intimacy over 70 and well beyond. But various issues could prevent you from getting intimate in your gilded years. We’re going to assume ...

7. J&J, Bristol Myers lose challenges to US drug price ...

   www.aol.com/news/j-j-bristol-myers-lose...

   Eliquis brought Bristol Myers about $8.52 billion in U.S. sales last year, while J&J recorded $2.36 billion in Xarelto sales. Eliquis is shared with Pfizer and Xarelto with Bayer, which were not ...

8. Informant Questionnaire on Cognitive Decline in the Elderly

   en.wikipedia.org/wiki/Informant_Questionnaire_on...

   It has also been found to correlate with change in cognitive test scores over time. [3] The IQCODE has near-zero correlations with a person's level of education or with their intelligence earlier in life. This is in contrast to conventional dementia screening tests like the Mini-Mental State Examination, which are affected by education and ...

9. 20 useful and innovative gadgets to make life easier for ...

   www.aol.com/lifestyle/products-to-make-life...

   20 useful and innovative gadgets to make life easier for seniors who live alone. ... In fact, over 1,000 reviewers at Walmart have given this small but mighty tool a 4.8-star rating.