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Some people who are diagnosed with treatment-resistant depression may have an underlying undiagnosed health condition that is causing or contributing to their depression. Endocrine disorders like hypothyroidism , Cushing's disease , and Addison's disease are among the most commonly identified as contributing to depression .
This type of depression often occurs due to biological reasons. Since symptoms are due to an internal phenomena, prevalence rates tend to be higher in older adults and more prevalent among women. [6] Although endogenous depression has been associated with increased age, there have been few attempts to evaluate this fully. More research is ...
The risk factors [110] for treatment resistant depression are: the duration of the episode of depression, severity of the episode, if bipolar, lack of improvement in symptoms within the first couple of treatment weeks, anxious or avoidant and borderline comorbidity and old age. Treatment resistant depression is best handled with a combination ...
The loss of these hormones, which are a normal part of aging for women, can have a systemic impact on health, especially cardiovascular health. ... and consider treatment options. 3. Depression ...
Treatment is hormone replacement therapy of testosterone. [11] [12] [13] In females, hypoandrogenism consist of loss of libido, decreased body hair growth, depression, fatigue, vaginal vasocongestion (which can result in cramps), vasomotor symptoms (e.g., hot flashes and palpitations), insomnia, headaches, osteoporosis and reduced muscle mass.
Vagus nerve stimulation is an alternative treatment that has been proven effective in treating depression, especially for people who have been resistant to four or more treatments. [3] Some of the unique benefits of vagus nerve stimulation include improved neurocognitive function and sustained clinical response.
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