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Crohn's disease affects about 3.2 per 1,000 people in Europe and North America; [12] it is less common in Asia and Africa. [21] [22] It has historically been more common in the developed world. [23] Rates have, however, been increasing, particularly in the developing world, since the 1970s.
The following is a list of notable people diagnosed with Crohn's disease. Crohn's disease is a type of inflammatory bowel disease that may affect any part of the gastrointestinal tract from mouth to anus , causing a wide variety of symptoms .
[7] [9] In 2015, a worldwide total of 47,400 people died due to inflammatory bowel disease (UC and Crohn's disease). [6] The peak onset is between 30 and 40 years of age, [12] with a second peak of onset occurring in the 6th decade of life. [178] Ulcerative colitis is equally common among men and women.
It has been shown to be useful in the treatment of mild to moderate Crohn's disease, [6] and in maintaining remission. [7] It is also effective when used in combination with antibiotics to treat active Crohn's disease. [8] Budesonide is released in the ileum and right colon, and therefore has a topical effect against disease in that area. [6]
Heredity, also called inheritance or biological inheritance, is the passing on of traits from parents to their offspring; either through asexual reproduction or sexual reproduction, the offspring cells or organisms acquire the genetic information of their parents.
The effect of shared environment, c 2, contributes to similarity between siblings due to the commonality of the environment they are raised in. Shared environment is approximated by the DZ correlation minus half heritability, which is the degree to which DZ twins share the same genes, c 2 =DZ-1/2h 2.
Autosomal dominant A 50/50 chance of inheritance. Sickle-cell disease is inherited in the autosomal recessive pattern. When both parents have sickle-cell trait (carrier), a child has a 25% chance of sickle-cell disease (red icon), 25% do not carry any sickle-cell alleles (blue icon), and 50% have the heterozygous (carrier) condition. [1]
The F 2-generation shows a 1:2:1 ratio of red: light pink: white. If two parents are mated with each other who differ in one genetic characteristic for which they are both homozygous (each pure-bred), all offspring in the first generation (F 1 ) are equal to the examined characteristic in genotype and phenotype showing the dominant trait.