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[1] Malaria is the deadliest among infectious diseases, accounting for approximately 429,000 human deaths in 2015 as of the latest estimate by the World Health Organization. [2] In humans, malaria can be caused by five Plasmodium parasites, namely P. falciparum, P. vivax, P. malariae, P. ovale and P. knowlesi. [3]
While a series of research publications came out of the Stateville Penitentiary experiments, the results had a minimal long-term impact on malaria treatment methods. The main legacy of the study is instead the ethical contention raised by prisoner experimentation , manifesting in the trials of Nazi Germany for its experiments on human subjects.
Plasmodium berghei is a single-celled parasite causing rodent malaria.It is in the Plasmodium subgenus Vinckeia.. Originally, isolated from thicket rats in Central Africa, P. berghei is one of four Plasmodium species that have been described in African murine rodents, the others being P. chabaudi, P. vinckei, and P. yoelii.
In 1880, Alphonse Laveran discovered that the causative agent of malaria is a parasite. [2] Detailed work of Golgi in 1886 demonstrated that in some patients there was a relationship between the 72-hour life cycle of the parasite and the chill and fever patterns in the patient. [2] The same observation was found for parasites with 48-hour ...
Malaria is a mosquito-borne infectious disease that affects vertebrates and Anopheles mosquitoes. [6] [7] [3] Human malaria causes symptoms that typically include fever, fatigue, vomiting, and headaches. [1] [8] In severe cases, it can cause jaundice, seizures, coma, or death.
Grassi authored more than 250 scientific papers and, in collaboration with his students and colleagues, wrote another 100. 1898. Rapporti tra la malaria e peculiari insetti (zanzaroni e zanzare palustri). R. C. Accad. Lincei 7:163–177. 1899. Ancora sulla malaria. R. C. Accad. Lincei 8:559–561. with Bignami, A. and Bastianelli, G.. 1899.
The logo of the Drugs for Neglected Diseases initiative (DNDi) The Drugs for Neglected Diseases initiative (DNDi) is a collaborative, patients' needs-driven, non-profit drug research and development (R&D) organization that is developing new treatments for neglected diseases, notably leishmaniasis, sleeping sickness (human African trypanosomiasis, HAT), Chagas disease, [1] malaria, filarial ...
Plasmodium vivax is a protozoal parasite and a human pathogen.This parasite is the most frequent and widely distributed cause of recurring malaria. [2] Although it is less virulent than Plasmodium falciparum, the deadliest of the five human malaria parasites, P. vivax malaria infections can lead to severe disease and death, often due to splenomegaly (a pathologically enlarged spleen).