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Sidney Farber's work was instrumental in showing that effective pharmacological treatment of cancer was possible Jane C. Wright pioneered the use of the drug methotrexate to treat breast cancer and skin cancer. Shortly after World War II, a second approach to drug therapy of cancer began.
It is the source of chemotherapy drugs: topotecan and irinotecan. 1968 – Japanese Dr. Tanaka pioneers the treatment of metastatic breast cancer with cryoablation, resulting in prolonged survival [24] [25] [26] 1972 – UK and other European countries approve tamoxifen for breast cancer
Doxorubicin, sold under the brand name Adriamycin among others, is a chemotherapy medication used to treat cancer. [10] This includes breast cancer, bladder cancer, Kaposi's sarcoma, lymphoma, and acute lymphocytic leukemia. [10] It is often used together with other chemotherapy agents. [10] Doxorubicin is given by injection into a vein. [10]
As most chemotherapy drugs kill cancer cells in this manner, defective apoptosis allows survival of these cells, making them resistant. Many chemotherapy drugs also cause DNA damage, which can be repaired by enzymes in the cell that carry out DNA repair. Upregulation of these genes can overcome the DNA damage and prevent the induction of apoptosis.
A combination of two types of therapeutic agents selectively killed breast cancer cells in a clinical trial, offering hope for a new treatment for triple-negative breast cancer.
Undergoing treatment for breast cancer has been a life-changing experience, but I have emerged stronger and more resilient and have found a renewed purpose and meaning in my chosen profession ...
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