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Orally administered contraception for dogs and cats became available in Europe in 1963, followed by the US in the 1970s. [4] [5] The initial products were mostly progestin-based treatments implemented for sterilization. One of the first drugs sold was medroxyprogesterone acetate (MPA).
The natural cycle of spontaneous ovulation occurs in species such as cows. [21] There is a great demand for ovulation to be induced in cattle, as it allows farmers to synchronize their cattle to ovulate at the same time, helping improve the efficiency of dairy farming. [ 22 ]
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The following will cover the advancements of female fertility agents, major causes of female infertility. Next, it emphasizes on common female fertility agents in terms of their mechanism of action, side effects, fetal consideration and clinical application and ended up by the introduction of supplements and herbal medicines for female infertility.
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When used in conjunction with in vitro fertilization (IVF), controlled ovarian hyperstimulation confers a need to avoid spontaneous ovulation, since oocyte retrieval of the mature egg from the fallopian tube or uterus is much harder than from the ovarian follicle. The main regimens to achieve ovulation suppression are: