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PP cells play an important role when it comes to the regulation of plasma glucose as they help to synthesize and release pancreatic polypeptide (PP). As PP cells secrete more pancreatic polypeptide, it has been shown to have a negative effect on insulin secretion giving it anorexic effects on intestinal functionality.
Pancreatic polypeptide (PP) is a polypeptide secreted by PP cells in the endocrine pancreas. It is a hormone and it regulates pancreatic secretion activities, and also impacts liver glycogen storage and gastrointestinal secretion. Its secretion may be impacted by certain endocrine tumours.
Exocrine cells constitute the acinar cells and the ductal cells. The endocrine cells constitute the beta cells which make insulin, alpha cells which secrete glucagon, delta cells which secrete somatostatin and the PP-cells which secrete pancreatic polypeptide. [3]
There are about 1 million islets distributed throughout the pancreas of a healthy adult human. While islets vary in size, the average diameter is about 0.2 mm. [5]:928 Each islet is separated from the surrounding pancreatic tissue by a thin, fibrous, connective tissue capsule which is continuous with the fibrous connective tissue that is interwoven throughout the rest of the pancreas.
Enteroendocrine cells are specialized cells of the gastrointestinal tract and pancreas with endocrine function. They produce gastrointestinal hormones or peptides in response to various stimuli and release them into the bloodstream for systemic effect, diffuse them as local messengers, or transmit them to the enteric nervous system to activate nervous responses.
The researchers discovered that mucus-producing cells in the intestines took in the highest amount of microplastics, with contaminants even entering the nucleus of the cell, which holds genetic ...
20287 Ensembl ENSG00000070031 ENSG00000274473 ENSMUSG00000038580 UniProt P09683 Q08535 RefSeq (mRNA) NM_021920 NM_011328 NM_001287171 NM_001309439 RefSeq (protein) NP_068739 NP_001274100 NP_001296368 NP_035458 Location (UCSC) Chr 11: 0.63 – 0.63 Mb Chr 7: 140.86 – 140.86 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Secretin is a hormone that regulates water homeostasis ...
The study, published in the journal Cell by Cell Press, concluded that extended fasting activates the adrenal glands, which then stops tissue regeneration during "periods of unstable nutrient supply."