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Enterocytes, or intestinal absorptive cells, are simple columnar epithelial cells which line the inner surface of the small and large intestines. A glycocalyx surface coat contains digestive enzymes. Microvilli on the apical surface increase its surface area.
Enterocytes (in the small intestine) known as colonocytes in the colon, are the most numerous and function primarily for nutrient absorption. Enterocytes express many catabolic enzymes on their exterior luminal surface to break down molecules to sizes appropriate for uptake into the cell.
Microbes found on intestinal epithelium are known to direct M cell development. For example, the type III secretion system effector protein SopB activates the transition of M cells from enterocytes. [6] M cells undergo the differentiation process for up to four days before reaching full maturation.
The enterocytes in the small intestinal mucosa contain digestive enzymes that digest specific foods while they are being absorbed through the epithelium. These enzymes include peptidase, sucrase, maltase, lactase and intestinal lipase. This is in contrast to the gastric glands of the stomach where chief cells secrete pepsinogen.
The small intestine tract: This is where absorption takes place. [2] [3] [4] The brush borders of the intestinal lining are the site of terminal carbohydrate digestions. The microvilli that constitute the brush border have enzymes for this final part of digestion anchored into their apical plasma membrane as integral membrane proteins.
Intestinal villi (sg.: villus) are small, finger-like projections that extend into the lumen of the small intestine.Each villus is approximately 0.5–1.6 mm in length (in humans), and has many microvilli projecting from the enterocytes of its epithelium which collectively form the striated or brush border.
Required for the small intestinal identity during development. In IEC-6 cells, conditional expression induced enterocyte and goblet like cells: 21081128 [13] 19386267 [14] 8552090 [15] CTNNB1: Catenin, beta: Paneth cell differentiation. Essential for stem cell/crypt maintenance. Villus and crypt morphogenesis with Tcf3 via c-Myc
The jejunum is the second part of the small intestine in humans and most higher vertebrates, including mammals, reptiles, and birds.Its lining is specialized for the absorption by enterocytes of small nutrient molecules which have been previously digested by enzymes in the duodenum.