Search results
Results From The WOW.Com Content Network
Fetal hemoglobin, or foetal haemoglobin (also hemoglobin F, HbF, or α 2 γ 2) is the main oxygen carrier protein in the human fetus.Hemoglobin F is found in fetal red blood cells, and is involved in transporting oxygen from the mother's bloodstream to organs and tissues in the fetus.
The normal hemoglobin types are Hemoglobin A (HbA), which makes up 95–98% of total hemoglobin in adults, Hemoglobin A2 (HbA2), which constitutes 2–3% of total hemoglobin in adults, and Hemoglobin F (HbF), which is the predominant hemoglobin in the fetus during pregnancy, and may persist in small amounts in adults.
Hereditary persistence of fetal hemoglobin (HPFH) is a benign condition in which increased fetal hemoglobin (hemoglobin F, HbF) production continues well into adulthood, disregarding the normal shutoff point after which only adult-type hemoglobin should be produced.
n/a Ensembl ENSG00000213934 n/a UniProt P69891 n/a RefSeq (mRNA) NM_000559 n/a RefSeq (protein) NP_000550 n/a Location (UCSC) Chr 11: 5.25 – 5.25 Mb n/a PubMed search n/a Wikidata View/Edit Human Hemoglobin subunit gamma-1 is a protein that in humans is encoded by the HBG1 gene. Function The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow ...
A variant hemoglobin, called fetal hemoglobin (HbF, α 2 γ 2), is found in the developing fetus, and binds oxygen with greater affinity than adult hemoglobin. This means that the oxygen binding curve for fetal hemoglobin is left-shifted (i.e., a higher percentage of hemoglobin has oxygen bound to it at lower oxygen tension), in comparison to ...
Hemoglobin Portland II (also referred to as ζ 2 β 2 or HbE Portland-2) is a form of hemoglobin existing at low levels during embryonic and fetal life, composed of two zeta chains and two beta chains. It is quite unstable, more so than even hemoglobin Gower 1, and breaks down very rapidly under stress. [4]
This enables fetal hemoglobin to absorb oxygen from adult hemoglobin in the placenta, where the oxygen pressure is lower than at the lungs. Around 6 months of age after birth, the gamma chains will gradually be replaced by beta chains. This new hemoglobin structure is known as hemoglobin A, composed of two alpha and two beta chains (2α2β). [4]
F-hemoglobin (F-Hb) usually refers to hemoglobin in blood from rectal bleeding (fecal hemoglobin), but may also refer to Hemoglobin F (fetal hemoglobin). Topics referred to by the same term This disambiguation page lists articles associated with the title F-Hemoglobin .