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Alcohol's acute effects on GABAergic enhancement and NMDA suppression cause alcohol induced neurotoxicity and kindling, or worsening of alcohol withdrawal symptoms with each subsequent withdrawal period. This may cause CNS depression leading to acute tolerance to these withdrawal effects.
After binge drinking, unconsciousness can occur and extreme levels of consumption can lead to alcohol poisoning and death (a concentration in the blood stream of 0.40% will kill half of those affected [32] [medical citation needed]). Alcohol may also cause death indirectly, by asphyxiation from vomit.
For instance, alcohol consumption by a pregnant woman can lead to an incurable and damaging condition known as fetal alcohol syndrome, which often results in cognitive deficits, mental health problems, an inability to live independently and an increased risk of criminal behaviour, all of which can cause emotional stress for parents and caregivers.
How drinking alcohol can affect your health. Associated Press. January 5, 2025 at 11:50 AM. ... Almost half of the people who die from alcohol-related causes die before the age of 50.
It is possible in some cases that excessive alcohol use, via a kindling mechanism, can cause the development of a chronic substance-induced psychotic disorder, i.e. schizophrenia. The effects of an alcohol-related psychosis include an increased risk of depression and suicide as well as psychosocial impairments. [135]
Extreme levels of consumption can cause alcohol poisoning and death; a concentration in the blood stream of 0.36% will kill half of those affected. [2] [3] [4] Alcohol may also cause death indirectly by asphyxiation, caused from vomiting. Alcohol can greatly exacerbate sleep problems.
"Alcohol is a well-established, preventable cause of cancer responsible for about 100,000 cases of cancer and 20,000 cancer deaths annually in the United States,” Murthy said in a statement ...
Alcohol-related dementia can produce a variety of psychiatric problems including psychosis (disconnection from reality), depression, anxiety, and personality changes. Patients with alcoholic dementia often develop apathy, related to frontal lobe damage, that may mimic depression. [ 3 ]